In an influential series of opinion pieces published in early 2014 (see introductory comment by Macleod et al., 2014), the medical journal The Lancet tackled the issue of “increasing value, reducing waste” in biomedical research. This series laid out in detail the issues that had led Chalmers & Glasziou to conclude in 2009 that 85% of investment in biomedical research was wasted.