Rogue Scholar Beiträge

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Veröffentlicht in GigaBlog

GigaScience’s T2T Series has now launched, with our first papers showcasing new Telomere-to-Telomere methods and genomic data sets. While the first draft of the Human Genome was declared complete in April 2003, it took a further two decades for the publication of the first complete, gapless sequence of a human genome in March 2022.

Veröffentlicht in Henry Rzepa's Blog

Calicheamicin is a natural product with antitumour properties discovered in the 1980s, with the structure shown below. As noted elsewhere, this structure has many weird properties, including amongst other features an unusual “enedidyne” motif and the presence of an iodo group on an aromatic ring.

Veröffentlicht in Risk Taker!

Modeling Principles Almost all, if not all, applied science is based on the idea of a model. There are problems in the real world, and we would like to create a theory to solve such problems. One of the pillars or the main foundation of quantitative modeling is its effectiveness. But how can a model be effective? By demonstrating that it is simple, reproducible, and applicable in other areas of knowledge.

Veröffentlicht in Henry Rzepa's Blog

The Masamune-Bergman reaction[cite]10.1039/C29710001516[/cite],[cite]10.1021/ja00757a071[/cite] is an example of  a highly unusual class of chemical mechanism[cite]10.1021/cr4000682[/cite] involving the presumed formation of the biradical species shown as Int1 below by cyclisation of a cycloenediyne reactant. Such a species is  so reactive that it will be quickly trapped, as for example by dihydrobenzene to form

Veröffentlicht in Bastian Greshake Tzovaras

A video of Panoramax in action. Starting out with a map view which has small orange lines for where images are available. Then going into the actual 360 degree images and moving around. Above: a video showcasing the panoramax viewer, with a map to see where (most [1] ) images are, and the 360º views.

Veröffentlicht in chem-bla-ics

Scholia is a visual layer on top of Wikidata providing a rich user experience for browing scholarly research related knowledge. I am using the combinatie for various things, including exploring new research topics (a method, compound, or protein I do not know so much about yet), indexing notable research output (including citations), progress of Citation Typing Ontology uptake, etc.

Veröffentlicht in Triton Station

Given recent developments in the long-running hunt for dark matter and the difficulty interpreting what this means, it seems like a good juncture to re-up* this: The history of science is a decision tree. Vertices appear where we must take one or another branching. Sometimes, we take the wrong road for the right reasons. A good example is the geocentric vs. heliocentric cosmology.