We have a new paper out! I am a bit late with this post, since the accepted version went online in December 2020, and the final version appeared a few weeks ago. It will shortly appear in a finished issue of the journal so I can tell myself that I am not too late yet. What’s it about? A complex of TACC3-chTOG-clathrin-GTSE1 is important for stabilising the mitotic spindle during cell division.

During the pandemic, many virtual seminar programmes have popped up. One series, “Motors in Quarantine“, has been very successful. It’s organised by my colleagues Anne Straube, Alex Zwetsloot and Huong Vu. Anne wanted to know if attendees of the seminar series were a fair representation of the field. We know the geographical location of the seminar attendees, but the challenge was to find a way to examine research activity at a country level.

The coronavirus crisis has meant that scientific meetings and seminars have moved online. This change has led to me wondering: why don’t scientists give talks the way that musicians do gigs? The idea is: after posting a preprint or publishing a paper, a scientist advertises that they will livestream a seminar to explain the work. Attendance is free.

I’m posting this the morning after generating a graph, and it’s already out-of-date. During the worldwide COVID-19 outbreak, preprint servers such as bioRxiv and medRxiv have again shown that they are the most effective way of communicating science rapidly. A collection of all papers on COVID-19 deposited on these two servers is available here, and it is growing daily.

As a scientist and a music lover, I see parallels in the process of doing science and in making music. They’re both creative endeavours after all. The lab’s latest paper is like an album release. The authors of the paper are like the players in the band. See, the analogy works quite well.

I run a Masters module called MD997. Over six weeks, students have to write a grant proposal and then assess their peers’ proposals at a mock grant panel. Each student bases their proposal on a paper. They present that paper to the class and then they write their proposal using the paper as a springboard. I refreshed my paper list this year to consist of solely papers published (or posted on bioRxiv) in 2019. The previous list is here.

We have a new paper out! You can access it here. The paper in a nutshell We have discovered a new class of trafficking vesicle inside cells. These vesicles are very small (30 nm across) and we’ve called them intracellular nanovesicles, or INVs for short. What is a trafficking vesicle? Humans are built from lots of cells.

This post follows on from the last post on BBSRC Responsive Mode funding. Another frequent question from applicants is: “How much can I ask for?” One answer is: the same amount as successful grants. This information is freely available and can be downloaded from the UKRI website. All awarded grants can be searched (even those that have completed) using their database.

This month I spent a lot of time evaluating proposals for BBSRC Committee D. At the same time a number of my colleagues were also preparing BBSRC applications for the next round. A question came up: Is it best to put Track Record before Case For Support or vice versa? If you have no idea what I mean, a brief explanation. The “Case for Support” is a document up to 8 pages which is the meat of a BBSRC Response Mode application.

We have a new preprint out – it is a cautionary tale about using GFP nanobodies in cells. This short post gives a bit of background to the work. Please read the paper if you are interested in using GFP nanobodies in cells, you can find it here. Paper in a nutshell: Caution is needed when using GFP nanobodies because they can inhibit their target protein in cells.