[[By Luisa Robbez-Masson (Barts Cancer Institute, Queen Mary University, London, UK)]{style=“font-family: "helvetica neue" , "arial" , "helvetica" , sans-serif; font-size: small;”}]{style=“font-size: 11pt; line-height: 115%; mso-ansi-language: EN-GB; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-language: AR-SA; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: Calibri; mso-fareast-language: EN-US;