Pubblicato in Henry Rzepa's Blog

Science is rarely about a totally new observation or rationalisation, it is much more about making connections between known facts, and perhaps using these connections to extrapolate to new areas (building on the shoulders of giants, etc). So here I chart one example of such connectivity over a period of six years.

References

Inglese

The Houk–List transition states for organocatalytic mechanisms revisited

Pubblicato in Chem. Sci.
Autori Alan Armstrong, Roberto A. Boto, Paul Dingwall, Julia Contreras-García, Matt J. Harvey, Nicholas J. Mason, Henry S. Rzepa

The ten year old Houk–List model for rationalising the origin of stereoselectivity in the organocatalysed intermolecular aldol addition is revisited, using a variety of computational techniques that have been introduced or improved since the original study.