Brian de Alwis has written a cool Apple Script called OpenDOI that adds support for resolving doi: and hdl: URLs using Safari on a Mac. With it installed, links such as hdl:10101/npre.2008.1760.1 and doi:10.1093/bib/bbn022 become clickable, without having to stick a HTTP proxy in front of them. Seems that an obvious extension to this would be to add support for LSIDs.