We have a new paper out. It’s about how chromosomes get shared during cell division. The paper in a nutshell In science-speak Misaligned chromosomes outside the exclusion zone become *ensheathed *in multiple layers of endomembranes. This event consigns the chromosome to missegregation and generates a micronucleus. In normal language Cells can make mistakes when they divide.

We have a Q&A with author Matthieu Foll from the WHO International Agency for Research on Cancer (IARC) on his new GigaScience paper presenting multi-omic data from rare lung neuroendocrine neoplasms and his experience having the precious Controlled Access data peer reviewed by named peer reviewers. As a journal focused on reproducibility of research GigaScience has a strict open-science policy, meaning

We have a new preprint out. This is a short post to describe our findings and highlight some of the software I developed for analysing cell migration and cell shape data.

We have a new paper out! This post is to explain what it’s about. Cancer cells often have gene fusions . This happens because the DNA in cancer cells is really messed up. Sometimes, chromosomes can break and get reattached to a different one in a strange way. This means you get a fusion between one gene and another which makes a new gene, called a gene fusion.

We have a new paper out! You can access it here.

The 2014 International Conference on Systems Biology (ICSB) was hosted in Australia’s most livable city and event, sport, culture and food capital – that is Melbourne, with GigaScience being proud to be one of the media partners.

Shedding light on what the Optical Mapping System can provide for genome analysis, here we present a guest posting from optical mapping pioneer and developer (and GigaScience Editorial Board Member), David C. Schwartz, who is a Professor of Chemistry and Genetics at the University of Wisconsin-Madison. ** Taking the Google Maps approach: providing comprehensive, scalable worldviews** We use maps in our daily lives to

[]{style=“font-family: "helvetica neue" , "arial" , "helvetica" , sans-serif;”} [Image Source: Serial/Trash]{style=“font-family: "helvetica neue" , "arial" , "helvetica" , sans-serif; font-size: xx-small;”} [Skin is not the only thing to wrinkle with age. Our genes also show signs of ageing – a process that can lead to cancer.

[Image Source: Serial/Trash]{style=“font-family: "arial" , sans-serif; line-height: 150%;”} [Cancer results from an accumulation of mistakes or abnormalities in genes that normally control cell survival, growth and migration. Genes are the instruction manual for our cells, and when these instructions are altered cells may begin to multiply (proliferate) uncontrollably.

[By Clare Finlay, a PhD student at the Wolfson Centre for Age-Related Disease, King’s College London]{style=“font-family: "helvetica neue" , "arial" , "helvetica" , sans-serif;”} [ ]{style=“font-family: "helvetica neue" , "arial" , "helvetica" , sans-serif;”} [Note: Clare was highly commended for her entry. Check back tomorrow to read her brilliant summary on the blog.]{style=“font-family: "helvetica neue" , "arial" , "helvetica" , sans-serif;