Messaggi di Rogue Scholar

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Pubblicato in Henry Rzepa's Blog

I am exploring the fascinating diverse facets of a recently published laboratory experiment for undergraduate students.[cite]10.1021/acs.jchemed.7b00566[/cite] Previously I looked at a possible mechanistic route for the reaction between an enal (a conjugated aldehyde-alkene) and benzyl chloride catalysed by base and a chiral amine, followed by the use of NMR coupling constants to assign relative stereochemistries.

Pubblicato in Henry Rzepa's Blog

Back in the days (1893) when few compounds were known, new ones could end up being named after the discoverer. Thus Feist is known for the compound bearing his name; the 2,3 carboxylic acid of methylenecyclopropane ( 1 , with Me replaced by CO 2 H). Compound 1 itself nowadays is used to calibrate chiroptical calculations[cite]10.1021/ct300359s[/cite], which is what brought it to my attention.