We have a new paper out. The title is New tools for ‘hot-wiring’ clathrin-mediated endocytosis with temporal and spatial precision . You can read it here. Cells have a plasma membrane which is the barrier between the cell’s interior and the outside world. In order to import material from outside, cells have a special process called endocytosis.

We were asked to write a Preview piece for Developmental Cell. Two interesting papers which deal with the insertion of amphipathic helices in membranes to influence membrane curvature during endocytosis were scheduled for publication and the journal wanted some “front matter” to promote them. Our Preview is paywalled – sorry about that – but I can briefly tell you why these two papers are worth a read.

Back of the envelope calculations for this post. An old press release for a paper on endocytosis by Tom Kirchhausen contained this fascinating factoid: If this is true it is absolutely staggering. Let’s check it out. A synaptic vesicle is ~40 nm in diameter.

This post is about a paper that was recently published. It was the result of a nice collaboration between me and Francisco López-Murcia and Artur Llobet in Barcelona. The paper in a nutshell The availability of clathrin sets a limit for presynaptic function Background Clathrin is a three legged protein that forms a cage around membranes during endoctosis.

We have a new paper out! You can read it here. I thought I would write a post on how this paper came to be and also about our first proper experience with preprinting. Title of the paper: Non-specificity of Pitstop 2 in clathrin-mediated endocytosis. In a nutshell: we show that Pitstop 2, a supposedly selective clathrin inhibitor acts in a non-specific way to inhibit endocytosis.