Messaggi di Rogue Scholar

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We have a new paper out! You can access it here. The paper in a nutshell We have discovered a new class of trafficking vesicle inside cells. These vesicles are very small (30 nm across) and we’ve called them intracellular nanovesicles, or INVs for short. What is a trafficking vesicle? Humans are built from lots of cells.

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This post follows on from the last post on BBSRC Responsive Mode funding. Another frequent question from applicants is: “How much can I ask for?” One answer is: the same amount as successful grants. This information is freely available and can be downloaded from the UKRI website. All awarded grants can be searched (even those that have completed) using their database.

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This month I spent a lot of time evaluating proposals for BBSRC Committee D. At the same time a number of my colleagues were also preparing BBSRC applications for the next round. A question came up: Is it best to put Track Record before Case For Support or vice versa? If you have no idea what I mean, a brief explanation. The “Case for Support” is a document up to 8 pages which is the meat of a BBSRC Response Mode application.

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We have a new preprint out – it is a cautionary tale about using GFP nanobodies in cells. This short post gives a bit of background to the work. Please read the paper if you are interested in using GFP nanobodies in cells, you can find it here. Paper in a nutshell: Caution is needed when using GFP nanobodies because they can inhibit their target protein in cells.

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This week Erick Martins Ratamero and I put up a preprint on vesicle packing. This post is a bit of backstory but please take a look at the paper, it’s very short and simple. The paper started when I wanted to know how many receptors could fit in a clathrin-coated vesicle. Sounds like a simple problem – but it’s actually more complicated.

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I really dislike being asked “how big is your lab?”. The question usually arises at scientific meetings when you are chatting to someone during a break. Small talk can lead to some banal questions being asked, and that’s fine, but when this question is asked seriously, the person asking really just wants to compare themselves to you in some way.