While for much of its history since the great famine of the eighteenth century Ireland has been synonymous with mass emigration, the 23 rd ISMB (Intelligent Systems for Molecular Biology) meeting sailing into the regenerated “Silicon Docks” of Dublin last week was a homecoming of sorts for the annual gathering of the global Bioinformatics community.
**Open is the New Black **While the internet might still be raging over Tim Hunt’s comments about # distractlingsexy gender issues in the lab, and to a lesser extent Lior Pachtor’s recent provocative blog on the “myths” of bioinformatics code availability and licensing, here in Dublin this years BOSC conference was clear as ever about where they stand on both issues.
With our focus on large-scale biological data, mass spectrometry has been one area of particular interest and attention. Metabolomics involves the detection and quantification of small molecules (metabolites) in living organisms using mass spectrometers.
Sam Minot from Signature Science, LLC and Andy Kilianski from the Edgewood Chemical Biological Center are part of a team that has been trialling a new palm-sized DNA sequencer to test whether it can characterize viruses and bacteria.
The software application PLINK is one of the most widely used tools in bioinformatics, particularly for genome-wide association studies (GWAS) that look at genetic variants in different individuals to see if any variant is associated with a trait. With the advent of the thousand dollar genome, the computational demands being made on such programs are exploding.
*The field of synthetic biology, designing and building engineered biological systems through DNA synthesis and genetic engineering, is rapidly moving to a genome scale. In a similar trajectory to genomic sequencing and genome projects two decades ago, it has moved from engineering single genes, entire synthetic bacterial genomes (J Craig Venter’s notorious “Synthia”), to the eukaryotic organism stage.
When it comes to technology, GigaScience has always been open and willing to embrace new ways of integrating technology in its publishing processes, with the ultimate goal of working towards more reproducible, interactive and executable papers.
Sheer Heart Attack Diagnosis is key to beginning treatment for preventing coronary heart disease, the most common cause of heart attacks. One useful tool in the fight against this leading killer is magnetic resonance imaging, which allows the direct examination of blood flow to the myocardium of the heart.
Take a ride down chromosome highways with a novel web-based platform that allows sharing of private genetic data while maintaining privacy through a colourful dynamic visualization tool. The Human Genome Project offered new hope that discovering the genetic determinants which mediate chronic disease susceptibility would lead to new avenues for drug development and targeted therapy, yet over decade later the is disappointment
