Europe PMC and Open Targets develop Lit-OTAR framework unearthing over 48 million unique associations that can be leveraged for drug discovery Identifying drug targets is a critical and intricate part of drug discovery. This requires scientists to look at many sources of evidence. They use them to find links between drugs, targets, and diseases.

This is one of those posts of a molecule whose very structure is interesting enough to merit a picture and a 3D model. The study[cite]10.1126/science.aal1619[/cite] reports a molecular knot with the remarkable number of eight crossings.

Following on from my post there has been lots of discussion both in the comments to the post and also support and ideas on other blogs. I also had a good talk (I know, face to face, how archaic :) with Jeremy Frey about the idea. Here I want to collate a few of the comments and ideas. Jean-Claude makes a very good point in a comment on the original post. I believe it will be possible, with resources,Â

A whole series of things have converged in the last couple of days for me. First was Jean-Claude’s description of the work [1, 2] he and Brent Friesen of the Dominican University are doing putting the combi-Ugi project into an undergraduate laboratory setting. The students will make new compounds which will then be sent for testing as antimalarial agents by Phil Rosenthal at UCSF.