We have an analysis routine for proteomics data written for IgorPro. One output is a volcano plot . These plots show the fold change in one sample compared to another and plot that against a p-value to estimate how reproducible any changes observed are. This post is not about that software, but on the topic of how we can recreate this plot in R . What steps need to be considered?

The Center for Antibody Technologies headed by Professor Andreas Laustsen-Kiel (Technical University of Denmark) used high-throughput methods to systematically analyze the venoms of the 26 most deadly snakes in sub-Saharan Africa. The results are now published in Gigascience . Each year, around 500,000 people in sub-Saharan Africa suffer from snake bites, causing an estimated 7,000 to 20,000 deaths.

Giardia, a protozoan parasite which people typically pick up through drinking infected water or contaminated food, can cause diarrhoea and stomach pains. New research published today in GigaScience , with supporting data in GigaDB, provides insights into the mechanisms that cause the symptoms of giardiasis. Currently more than 200,000 people are ill with giardiasis and there are 500,000 new cases a year.