Image design: Serial/Trash A number of genes have been implicated in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), also known as motor neurone disease, and Frontotemporal lobar degeneration (FTLD). However, the core biological processes involved in these disorders are extremely difficult to model and this is hampering the effort to develop treatments.

by Nina Rzechorzek (University of Edinburgh, UK) Short-listed for Access to Understanding 2013 How do nerve cells die? Many human diseases involve degeneration of the nervous system – a system of interconnecting nerve cells, allowing us to sense and respond to our environment. All of these disorders are incurable and fatal. Most of them share a common feature – aggregation of abnormal protein within nerve cells.